Structural Dynamics of Aqueous Solutions#

Welcome to the Stuctural Dynamics of Aqueous Solutions (SDAQS) group website.
@ Physics Department, Stockholm University.
Follow us on social media: @FoivosPerakis

Our vision
- to revolutionize the understanding of nanoscale fluctuations and non-equilibrium dynamics in aqueous biological solutions, through advanced coherent X-ray scattering methods, interdisciplinary collaboration and impactful dissemination of our research findings,
- to facilitate an inclusive international research environment, where students, postdocs and staff can be creative problem-solvers and life-long learners.

Focus areas
- Nanoscale fluctuations in supercooled aqueous solutions
- Structural dynamics of protein hydration water
- Non-equilibrium biomolecular dynamics in crowded environments

Methodologies
- Experiments at X-ray synchrotrons and Free Electron Lasers (XFELs)
- X-ray Photon Correlation Spectroscopy (XPCS)
- Time-resolved X-ray Scattering (SAXS, WAXS)
- Advanced sample delivery techniques
- Molecular Dynamics (MD) simulations and HPC data methods

Recent highlights#

Nanocrystallites Modulate Intermolecular Interactions in Cryoprotected Protein Solutions. Filianina et al.
J. Phys. Chem. B, 127, 6197–6204 (2023)

Melting Domain Size and Recrystallization Dynamics of Ice Revealed by Time-Resolved X-ray Scattering. Yang et al.
Nat. Commun., 14, 3313 (2023)

Coherent X-ray Scattering Reveals Nanoscale Fluctuations in Hydrated Proteins.
Bin et al.
J. Phys. Chem. B, 127, 4922–4930 (2023)

Liquid-liquid phase separation in supercooled water from ultrafast heating of low-density amorphous ice. Amann-Winkel et al.
Nat. Commun., 14, 442 (2023)

Resolving molecular diffusion and aggregation of antibody proteins with megahertz X-ray free-electron laser pulses. Reiser et al.
Nat. Commun., 13, 1-10 (2022)

Nanofocused x-ray photon correlation spectroscopy. Berkowicz et al.
Phys. Rev. Res., 4, L032012 (2022)